CHEMICAL SYNTHESIS OF ALL-TRANS RETINOYL BETA-GLUCURONIDE.

Chemical synthesis of all-trans retinoyl beta-glucuronide.

All-trans retinoyl fluoride reacts with the 3,6-lactone of glucuronic acid in slightly alkaline solution to give the lactone of retinoyl beta-glucuronide, along with other verona wig retinoyl glucurono-lactones, in about 60% yield.Hydrolysis of the lactone with very dilute alkali gives the free acid, retinoyl beta-glucuronide, in about 80% yield.Pu

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